Medicinal Chemistry Seminar Series

Lisa Berreau, Ph.D.

Guest Speaker: Dr. Raphael Franzini, MDCH

Developing Carbon Monoxide Delivery Molecules for Biological Applications

Abstract: Although known for its toxicity, carbon monoxide (CO) is now recognized to produce beneficial health effects at low concentration in humans, including anti-inflammatory, cardioprotective, and anti-cancer effects. To probe the biological pathways leading to these effects, and for potential therapeutic applications, highly controlled CO delivery molecules are needed. Fluorescent flavonols are gaining interest as trackable and triggered CO delivery molecules, being used both independently and as part of nanomaterials. In this presentation, I will outline current challenges regarding CO delivery, and how flavonol motifs are being developed to advance the field. Applications in biological models will be discussed.

Meet & Greet: Open to all

Jan 11 @ 1:00 PM – 1:45

3-Chairs Lounge